Drug Discovery Research Screening Libraries
AdipoGen Zilpaterol hydrochloride
Chemical. CAS 119520-06-8. Formula C14H19N3O2 . HCl. MW 297.78. Synthetic. Synthetic beta2-adrenoreceptor agonist that binds with the muscle beta-adrenoreceptors, leading to the activation of protein kinase A, an enzyme responsible for changes in protein synthesis and degradation, in particular in skeletal muscles. Due to its partial activity towards beta1-adrenoreceptors, has also the potential to affect cardiac muscle. In consequence, application of zilpaterol leads to preferential induction of fast glycolytic fibre types over slow oxidative fibre types resulting in enhanced growth efficiency and carcass leanness. Used as a veterinary drug in cattle to enhance growth performance in several countries.
AdipoGen DNER ED hFc h rec
Protein. The extracellular domain of human DNER aa 29-637 is fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.06EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
Apexbio Technology LLC EZ Cap™ EPO mRNA (ψUTP),100ug (1mg/mL)
The human erythropoietin (EPO) protein encoded by EPO mRNA is a hormone that controls erythropoiesis or erythropoiesis. EPO also plays a role in wound healing and the brain's response to nerve damage. Studies have shown that transfection of EPO mRNA in vivo leads to a significant increase in reticulocyte and hematocrit measurement.This mRNA is capped using a co-transcriptional capping method, which results in the naturally occuring Cap 1 structure with high capping efficiency. It is polyadenylated, modified with ψUTP and optimized for mammalian systems. The addition of ψUTP and poly(A) tail can reduce host cell immune response and enhance mRNA stability. It can simulate the function of a fully processed mature mRNA.Other sizes are also available. Please inqury us for quote.
AdipoGen Zilpaterol hydrochloride
Chemical. CAS 119520-06-8. Formula C14H19N3O2 . HCl. MW 297.78. Synthetic. Synthetic beta2-adrenoreceptor agonist that binds with the muscle beta-adrenoreceptors, leading to the activation of protein kinase A, an enzyme responsible for changes in protein synthesis and degradation, in particular in skeletal muscles. Due to its partial activity towards beta1-adrenoreceptors, has also the potential to affect cardiac muscle. In consequence, application of zilpaterol leads to preferential induction of fast glycolytic fibre types over slow oxidative fibre types resulting in enhanced growth efficiency and carcass leanness. Used as a veterinary drug in cattle to enhance growth performance in several countries.
AdipoGen ANGPTL4 FLD h rec
Protein. Fibrinogen-like domain of human ANGPTL4 aa 166-406 is fused at the N-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. ANGPTL4 Angiopoietin-like protein 4 mainly expressed in endothelial cells hypoxia-induced. Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain FLD. Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase LPL converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions.
AdipoGen Bafilomycin A1 high purity
Chemical. CAS 88899-55-2. Formula C35H58O9. MW 622.8. Bafilomycin A1, a macrolide antibiotic, is a highly potent, selective inhibitor of vacuolar H-ATPases. Bafilomycin A1 is a potent inhibitor of cellular autophagy either by blocking autophagosome-lysosome fusion or by blocking lysosomal degradation. Bafilomycin A1 has several other biological properties. It induces apoptosis or acts as an ionophore, meaning it can transfer K ions across biological membranes. Bafilomycin A1 can induce mitochondrial swelling in the presence of K ions, stimulate the oxidation of pyrimidine nucleotides and uncouple oxidative phosphorylation. Inhibition of V-ATPase activity with bafilomycin A1 led to the exacerbation of NLRP3 inflammasome activation in human monocytes in response to LPS. Bafilomycin A1 also significantly inhibited SARS-CoV-2 replication. In cancer, bafilomycin A1 has been shown to inhibit the growth of tumor cells by blocking the acidification of lysosomes.
AdipoGen 7DW8-5
Chemical. CAS 1056025-00-3. Formula C41H72FNO9. MW 742. . Glycolipid derivative of alpha-GalCer. Potent stimulator of invariant natural killer T iNKT cells 140-fold lower EC50 compared to alpha-GalCer. Specific ligand strongest binding affinity of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells with. Show to induce secretion of key cytokines such as IFN-gamma and IL-12, and activate autologous dendritic cells, as well as binding to CD1d and the invariant T cell receptor invTCR. Potent vaccine adjuvant ~100 times stronger than alpha-GalCer that can harness and amplify the immunotherapeutic potential of NKT cells to treat certain microbial infections such as malaria and HIV. Potential immunotherapeutic to treat cancer, infectious diseases and autoimmune diseases.
AdipoGen Helvolic acid
Chemical. CAS 29400-42-8. Formula C33H44O8. MW 568.7. Isolated from Aspergillus fumigatus Strain WDMH-35. Steroidal triterpene. Antibiotic. Antibacterial. Shows broad activity against Gram positive and negative bacteria. Mycotoxin. Antifungal. Antitumor agent. Cytotoxic against different human cancer cells. Antituberculosis agent. Oxidized LDL uptake inhibitor. Phytotoxin. Inhibitor of the protein biosynthesis through archeal elongation factor 2 EF-2.
AdipoGen Procyanidin A2
Chemical. CAS 41743-41-3. Formula C30H24O12. MW 576.5. Isolated from grape seeds Vitis vinifera L. A-Type proanthocyanidine. Potent antioxidant. Free radical scavenger and lipid peroxidation inhibitor. Potent low-density lipoprotein LDL oxidation inhibitor. Antidiabetic. Prevents islet cell apoptosis, hyperglycemia and type 2 diabetes through its antioxidant properties. Antibacterial agent. Antiviral. Shown to inhibit viral replication of canine distemper virus CDV. Glycosyltransferase B GTFB inhibitor.
AdipoGen Paeoniflorin
Chemical. CAS 23180-57-6. Formula C23H28O11. MW 480.46. Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor LXR agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects.
Selleck Chemical LLC Human Endogenous Metabolite Compound Library 100uL/well
1013 small collections of human endogenous metabolites, involving multiple metabolic pathways, which can be used for high-throughput screening, opening up new ways for humans to treat various diseases such as tumors. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Enzo Life Sciences SCREEN-WELL Nuclear Receptor ligand library (500 µl/well)
The SCREEN-WELL Nuclear Receptor Ligand Library contains 74 compounds with defined, putative and potential activity at nuclear receptors. Receptor agonists and antagonists are included. The library consists of a chemically diverse group of compounds which are supplied dissolved in DMSO at 10 mM (1mM for 5 compounds) and aliquoted into deep-well, 96-well plates at 500 µl or 100 µl per well. The library is an ideal tool for chemical genomics, receptor de-orphaning and other routine pharmacological applications. The library includes ligands for the following classes of nuclear receptors: AHR, CAR, ER, FXR, LXR, PPAR, PXR, RAR, RXR, VDR, and other steroid receptors. Long Term Storage: -80°C. Applications: HTS .
Enzo Life Sciences Matrix Metalloproteinase-10 (MMP-10) fluorometric drug discovery kit (1x96wells)
A QUANTIZYME Assay System. The MMP-10 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-10 (MMP-10, stromelysin-2) using a quenched fluorogenic peptide: OMNIMMP fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. Also included are active enzyme, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Alternative name: Stromelysin 2. Applications: Fluorescent detection, HTS Activity assay.
Apexbio Technology LLC DiscoveryProbe™ Autophagy Compound Library Plus 100uL/well(10 mM solution),96 Well Deep Well Plate
DiscoveryProbe Autophagy Compound Library is a collection of 486 small molecule compounds carefully selected based on published evidence and experimental validation for their modulatory activity on cellular autophagy pathways Autophagy a conserved cellular process regulated by molecules such as mTOR AMPK ULK1 and Beclin-1 is involved in maintaining cellular homeostasis by mediating the turnover of intracellular components Dysregulation of autophagic pathways contributes to the progression of various human disorders including cancer neurodegeneration and metabolic diseases making this library suitable for biomedical research This library offers compounds approved by regulatory agencies including FDA EMA and CFDA alongside well-characterized experimental tool inhibitors and activators such as rapamycin chloroquine bafilomycin A1 and wortmannin for evaluating autophagic flux in cellular or animal model systems
Enzo Life Sciences SCREEN-WELL Adrenergic ligand library (500 µl/well)
The adrenergic ligand library contains 83 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The adrenergic ligand library is 1 plate of the larger neurotransmitter library (BML-2810) which contains over 650 CNS receptor ligands. Long Term Storage: -80°C. Applications: HTS .